Secologanin synthase explained

In enzymology, a secologanin synthase is an enzyme that catalyzes the chemical reaction

loganin + NADPH + H⁺ + O₂

secologanin + NADP⁺ + 2 H₂O

The 4 substrates of this enzyme are loganin, NADPH, H⁺, and O₂, whereas its 3 products are secologanin, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is loganin:oxygen oxidoreductase (ring-cleaving). This enzyme participates in indole and ipecac alkaloid biosynthesis.

References

• Yamamoto H, Katano N, Ooi A, Inoue K. 2000. Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450. Phytochemistry.. 53. 7 - 12. 10656401. 10.1016/S0031-9422(99)00471-9.
• Strack D, Matern U, Schroder J. 2000. Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant. J.. 24. 797 - 804. 11135113. 10.1046/j.1365-313x.2000.00922.x.
• Yamamoto H, Katano N, Ooi Y and Inoue K. 1999. Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures. Phytochemistry. 50. 417 - 422. 10.1016/S0031-9422(98)00613-X.

External links

The CAS registry number for this enzyme class is .