| Department: | Lot-et-Garonne |
| Number: | 47 |
| Region: | Aquitaine |
| Prefecture: | Agen |
| Subprefectures: | Marmande Nérac Villeneuve-sur-Lot |
| Population: | 305,380 |
| Pop Date: | 1999 |
| Pop Rank: | 72nd |
| Density: | 57 |
| Area: | 5361 |
| Area Scale: | 9 |
| Arrond: | 4 |
| Cantons: | 40 |
| Communes: | 319 |
| President: | Pierre Camani |
| Pres Party: | Socialist Party |
| Img Coa: | blason47.PNG |
Lot-et-Garonne (Occitan (post 1500): Òlt e Garona) is a department in the southwest of France named after the Lot and Garonne rivers.
Lot-et-Garonne is one of the original 83 departments created during the French Revolution on March 4, 1790. It was created from part of the provinces of Guyenne and Gascogne. Some of the original southeastern cantons were separated from it in 1808 to form the department of Tarn-et-Garonne.
Lot-et-Garonne is part of the current region of Aquitaine and is surrounded by the departments of Lot, Tarn-et-Garonne, Gers, Landes, Gironde, and Dordogne.
Food-processing, chemicals, and pharmaceuticals are all major industries of the department.
The inhabitants of the department are called Lot-et-Garonnais.