Year 1464 (MCDLXIV) was a leap year starting on Sunday (link will display the full calendar) of the Julian calendar.
January - December
- Jehan Lagadeuc writes a Breton-French-Latin dictionary called the Catholicon. It's the first French dictionary as well as the first Breton dictionary of world history, and it will be published in 1499.
- In China, a small rebellion occurs in the interior province of Huguang, during the Ming Dynasty; a subsequent rebellion springs up in Guangxi, where a rebellion of the Miao people and Yao people forces the Ming throne to respond by sending 30,000 troops (including 1,000 Mongol cavalry) to aid the 160,000 local troops stationed in the region to crush the rebellion that will end in 1466.
- Pope Pius II himself shoulders the cross of the Crusader. Pope Pius II named Skanderbeg general captain of the Holy See. Skanderbeg was given the title Athleta Christi. This plan forced Skanderbeg to break his 10 year peace treaty with the Ottomans signed in 1463, by attacking the Turkish forces near Ohrid.